Aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones. Issue 24 (15th February 2016) - Tang, Shi
Abstract : A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta -selective tert -alkylation using AIBN and analogues as radical precursors was described. Abstract : A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta -selective C–H tert -alkylation using AIBN and analogues as radical precursors was described. This strategy provides an elusive and rapid means to 7- tert -alkylated isoquinolinediones, as well as the construction of tertiary alkyl–aryl C(sp 3 )–C(sp 2 ) bonds with positional selectivity.