Back cover: Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells. Issue 3 (3rd March 2016)

• Record Type: Journal Article
• Authors: Guillemot, Johann; Asselin, Marie‐Claude; Susan‐Resiga, Delia; Essalmani, Rachid; Seidah, Nabil G.
• Is Part Of: Molecular nutrition & food research. Volume 60:Issue 3(2016)
• Page Start: NA
• Page End: NA
• Publication Date: 2016-03-03
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201670035
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Mol. Nutr. Food Res . 2016, 60, 600–608. DOI:10.1002/mnfr.201500467 Hepatic iron overload increases cholesterol synthesis, contributing to the pathogenesis of hyper‐cholesterolemia. Incubation of human HepG2 cells with the iron chelator deferoxamine (DFO) stabilizes the LDL receptor (LDLR) mRNA, increases LDLR protein levels, and raises cell‐surface LDLR levels (green) and fluorescent diI‐LDL uptake (red). Thus, increased LDLR activity could be one of the underlying causes of the hypo‐cholesterolemia observed upon iron reduction. The authors thank E. Girard and H. Lambin for their work on the cover design.