Cascade Pd(ii)-catalyzed Wacker lactonization–Heck reaction: rapid assembly of spiranoid lactones. Issue 15 (13th January 2016)

• Record Type: Journal Article
• Authors: Albarghouti, Ghassan; Kotikalapudi, Ramesh; Lankri, David; Valerio, Viviana; Tsvelikhovsky, Dmitry
• Is Part Of: Chemical communications. Volume 52:Issue 15(2016)
• Page Start: 3095
• Page End: 3098
• Publication Date: 2016-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09923d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An unprecedented Pd-catalyzed cascade Wacker–Heck lactonization-cyclization sequence is reported. Abstract : An unprecedented Pd-catalyzed cascade Wacker–Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4- exo trig Heck-type cyclization is demonstrated.