Cascade Pd(ii)-catalyzed Wacker lactonization–Heck reaction: rapid assembly of spiranoid lactones. Issue 15 (13th January 2016) - Albarghouti, Ghassan
Abstract : An unprecedented Pd-catalyzed cascade Wacker–Heck lactonization-cyclization sequence is reported. Abstract : An unprecedented Pd-catalyzed cascade Wacker–Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4- exo trig Heck-type cyclization is demonstrated.