Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Issue 1 (8th January 2016)

• Record Type: Journal Article
• Authors: Hodgkinson, Conrad P.; Bareja, Akshay; Gomez, José A.; Dzau, Victor J.
• Is Part Of: Circulation research. Volume 118:Issue 1(2016)
• Publication Date: 2016-01-08
• Subjects: fibroblast growth factor -- heart diseases -- myocardial infarction -- regeneration -- stem cells; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.115.305373
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.