Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Issue 1 (8th January 2016) - Hodgkinson, Conrad P.
Abstract : In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.