A linker approach to phospholipopeptides. Issue 2 (11th May 2015)

• Record Type: Journal Article
• Authors: Li, Bonan; Liang, Jun F.
• Is Part Of: European journal of lipid science and technology. Volume 118:Issue 2(2016)
• Page Start: 273
• Page End: 278
• Publication Date: 2015-05-11
• Subjects: Conjugation -- Cross‐linker -- Lipopeptide -- Liposomes -- Peptides; Oils and fats, Edible -- Periodicals; Lipids -- Periodicals; 660.63
• DOI: 10.1002/ejlt.201400593
• Languages: English
• ISSNs: 1438-7697

Abstract

Abstract : Peptides and phospholipids are important macromolecules in both the chemistry and biology fields, but phospholipopeptides are barely found in nature and have not been studied. Here, we report a novel and efficient approach to the synthesis of phospholipidpeptides. By utilizing cross‐linkers, phospholipopeptides from peptides with varied sequences and lengths were produced from phosphatidylethanolamine at high (>90%) yield, mild conditions and good applied scopes for multiple substrates. Synthetic phospholipopeptides containing bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Practical applications: Phospholipopeptides are prone to hydrolysis by the endogenous phospholipase activity in cells. Synthetic phospholipopeptides containing a bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Cysteine‐containing peptides of varied sequences and lengths were linked to the heads of phosphatidylethanolamine through the amino group to form phospholipopeptides. Abstract : Cysteine‐containing peptides of varied sequences and lengths were linked to the heads of phosphatidylethanolamine through the amino group to form phospholipopeptides.