Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles. Issue 105 (13th October 2015)

• Record Type: Journal Article
• Authors: Borges, M.; Yu, S.; Laromaine, A.; Roig, A.; Suárez-García, S.; Lorenzo, J.; Ruiz-Molina, D.; Novio, F.
• Is Part Of: RSC advances. Volume 5:Issue 105(2015)
• Page Start: 86779
• Page End: 86783
• Publication Date: 2015-10-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra17661a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel dual T 1 / T 2 1 H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed. Abstract : We report a novel hybrid T 1 / T 2 dual MRI contrast agent by the encapsulation of SPIONs ( T 2 contrast agent) into an iron-based coordination polymer with T 1 -weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contrast agent for MRI.