Antioxidant and anti‐ageing activities of mycelia zinc polysaccharide from Pholiota nameko SW‐03. (13th January 2015)

• Record Type: Journal Article
• Authors: Zheng, Lan; Liu, Min; Zhai, Guo‐Yin; Ma, Zhao; Wang, Li‐Qin; Jia, Le
• Is Part Of: Journal of the science of food and agriculture. Volume 95:Number 15(2015:Dec. 15)
• Page Start: 3117
• Page End: 3126
• Publication Date: 2015-01-13
• Subjects: anti‐ageing activity -- antioxidant activity -- Pholiota nameko SW‐03 -- polysaccharide -- zinc; Food -- Periodicals; Agriculture -- Periodicals; 664
• DOI: 10.1002/jsfa.7048
• Languages: English
• ISSNs: 0022-5142

Abstract

Abstract: BACKGROUND: Edible fungi polysaccharides usually exhibit antioxidant activity, and zinc has been shown to have antioxidant properties. In the present work, Pholiota nameko SW‐03 was used as a vector of zinc biotransformation in order to obtain mycelia zinc polysaccharide (MZPS), and the structural characterization and anti‐ageing activity of MZPS were investigated. RESULTS: Pholiota nameko SW‐03 could accumulate zinc in the form of zinc‐enriched polysaccharide, and the zinc content in MZPS was 16.39 ± 0.72 mg g −1 . Three fractions (MZPS‐1, MZPS‐2 and MZPS‐3) were successfully isolated. The main fraction (MZPS‐2) with the highest antioxidant activity in vitro was composed of glucose, mannose, glucuronic acid, galactose, galacturonic acid and arabinose in a molar ratio of 172.59:5.29:4.61:4.20:1.01:1.00, with a weight‐average molecular weight of 13.63 kDa. The anti‐ageing capability was measured ind ‐galactose‐induced ageing mice, and the results showed that MZPS could improve antioxidant status (superoxide dismutase, total antioxidant capability, malondialdehyde and lipid peroxide), indicating that MZPS had strong anti‐ageing capability in vivo . CONCLUSION: This study suggested that organification of zinc through edible fungi liquid fermentation provided a novel method to produce MZPS, which might be used as a natural antioxidant to slow the progression of ageing. © 2014 Society of Chemical Industry