Pseudosaccharin amines as potent and selective KV1.5 blockers. Issue 21 (1st November 2015)

• Record Type: Journal Article
• Authors: Lloyd, John; Finlay, Heather J.; Kover, Alexander; Johnson, James; Pi, Zulan; Jiang, Ji; Neels, James; Cavallaro, Cullen; Wexler, Ruth; Conder, Mary Lee; Shi, Hong; Li, Danshi; Sun, Huabin; Chimalakonda, Anjaneya; Huang, Christine; Salvati, Mark; Levesque, Paul
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 21(2015)
• Page Start: 4983
• Page End: 4986
• Publication Date: 2015-11-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.02.066
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st015">Graphical abstract</title> <sec> <p id="sp0005">Synthesis of pseudosaccharin amines as K_V1.5 blockers led to the discovery of potent antagonists such as <bold>17d</bold>. These compounds had potent pharmacodynamic activity, however, showed off-target activities such as hemodynamic effects. <fig id="f0035" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgkfznq0bg" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>