Pseudosaccharin amines as potent and selective KV1.5 blockers. Issue 21 (1st November 2015) - Lloyd, John
Graphical abstract Synthesis of pseudosaccharin amines as KV1.5 blockers led to the discovery of potent antagonists such as 17d. These compounds had potent pharmacodynamic activity, however, showed off-target activities such as hemodynamic effects.