Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Lin, Syh-Jae; Huang, Ying-Cheng; Cheng, Po-Jen; Lee, Pei-Tzu; Hsiao, Hsiu-Shan; Kuo, Ming-Ling
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 348
• Page End: 355
• Publication Date: 2015-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.09.015
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">First study to demonstrate the expansion of iNKT cells from umbilical cord blood.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">IL-15 enhances α-GalCer-induced expansion of iNKT cells from adult or cord blood.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">IL-15 decreases early apoptosis and enhances IFN-γ production by iNKT cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">IL-15 enhances perforin expression and NK cytotoxicity of expanded iNKT cells.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">IL-15 benefits post-UCB transplant period when iNKT function remains poor.</p> </list-item> </list> </p> </sec> </abstract>