Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood. Issue 2 (December 2015) - Lin, Syh-Jae
Highlights First study to demonstrate the expansion of iNKT cells from umbilical cord blood. IL-15 enhances α-GalCer-induced expansion of iNKT cells from adult or cord blood. IL-15 decreases early apoptosis and enhances IFN-γ production by iNKT cells. IL-15 enhances perforin expression and NK cytotoxicity of expanded iNKT cells. IL-15 benefits post-UCB transplant period when iNKT function remains poor.