Furostanolic saponins from Trigonella foenum‐graecum alleviate diet‐induced glucose intolerance and hepatic fat accumulation. Issue 10 (14th August 2015)

• Record Type: Journal Article
• Authors: Hua, Yinan; Ren, Sidney Y.; Guo, Rui; Rogers, Olivia; Nair, Rama P.; Bagchi, Debasis; Swaroop, Anand; Nair, Sreejayan
• Is Part Of: Molecular nutrition & food research. Volume 59:Issue 10(2015:Oct.)
• Page Start: 2094
• Page End: 2100
• Publication Date: 2015-08-14
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201500197
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2451-sec-0010" sec-type="section"> <title>Scope</title> <p>The objective of this study was to evaluate the effect of fenugreek furostanolic saponins (Fenfuro<sup>TM</sup>) either alone or in combination with chlorogenic acid (GCB‐70<sup>TM</sup>) on insulin resistance in mice.</p> </sec> <sec id="mnfr2451-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Male C57BL/6J mice were subjected to a normal or high‐fat diet (HFD) and were randomly assigned to receive Fenfuro<sup>TM</sup>, GCB‐70<sup>TM</sup>, or their combination for 24 wk. Metabolic parameters, glucose tolerance, serum triglycerides, cardiac function, and hepatic insulin signaling were evaluated using indirect open‐circuit calorimetry, intraperitoneal glucose tolerance test, oil red O staining, echocardiography, and Western blotting, respectively. Intraperitoneal glucose tolerance test revealed glucose intolerance in the mice receiving HFD, which was attenuated by Fenfuro<sup>TM</sup>. Serum triglyceride that was elevated following an HFD was reconciled by both Fenfuro<sup>TM</sup> and the combination. HFD compromised myocardial contractile function, which was unaffected by the treatment. Insulin‐stimulated phosphorylation of Protein kinase B (AKT) in the liver was attenuated in mice receiving HFD, which was partially rescued by GCB‐70<sup>TM</sup>. Neither treatment altered metabolic parameters or energy expenditure.</p> </sec> <sec id="mnfr2451-sec-0030" sec-type="section"> <title>Conclusion</title> <p>Collectively, our data suggest that fenugreek furostanolic saponins and green coffee bean extract may have potential benefits in treating insulin resistance and related conditions.</p> </sec> </abstract>