Consumption of polyunsaturated fat improves the saturated fatty acid‐mediated impairment of HDL antioxidant potential. Issue 10 (12th August 2015)

• Record Type: Journal Article
• Authors: Cedó, Lídia; Metso, Jari; Santos, David; Sánchez‐Quesada, Jose Luís; Julve, Josep; García‐León, Annabel; Mora‐Brugués, Josefina; Jauhiainen, Matti; Blanco‐Vaca, Francisco; Escolà‐Gil, Joan Carles
• Is Part Of: Molecular nutrition & food research. Volume 59:Issue 10(2015:Oct.)
• Page Start: 1987
• Page End: 1996
• Publication Date: 2015-08-12
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201500336
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2438-sec-0010" sec-type="section"> <title>Scope</title> <p>The present study aimed to compare the effects of diets containing high‐fat, high‐cholesterol and saturated fatty acids (HFHC‐SFA) and HFHC‐polyunsaturated fatty acids‐containing (HFHC‐PUFA) diets on two major antiatherogenic functions of HDL, the HDL antioxidant function and the macrophage‐to‐feces reverse cholesterol transport.</p> </sec> <sec id="mnfr2438-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Experiments were carried out in mice fed a low‐fat, low‐cholesterol (LFLC) diet, an HFHC‐SFA diet or an HFHC‐PUFA diet in which SFAs were partly replaced with an alternative high‐linoleic and α‐linolenic fat source. The HFHC‐SFA caused a significant increase in serum HDL cholesterol and phospholipids as well as elevated levels of oxidized HDL and oxidized LDL. Replacing SFA with PUFA significantly reduced the levels of these oxidized lipoproteins and enhanced the ability of HDL to protect LDL from oxidation. The SFA‐mediated impairment of HDL antioxidant potential was not associated with the cholesterol content of the diet, obesity or insulin resistance. In contrast, the effect of the HFHC diets on fecal macrophage‐derived cholesterol excretion was independent of the fatty acid source.</p> </sec> <sec id="mnfr2438-sec-0030" sec-type="section"> <title>Conclusion</title> <p>SFA intake impairs the antioxidant potential of HDL and increases serum levels of oxidized lipoprotein species whereas the antioxidant potential of HDL is enhanced after PUFA consumption.</p> </sec> </abstract>