Fluoride as a factor initiating and potentiating inflammation in THP1 differentiated monocytes/macrophages. Issue 7 (October 2015)

• Record Type: Journal Article
• Authors: Gutowska, I.; Baranowska-Bosiacka, I.; Goschorska, M.; Kolasa, A.; Łukomska, A.; Jakubczyk, K.; Dec, K.; Chlubek, D.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 7(2015)
• Page Start: 1661
• Page End: 1668
• Publication Date: 2015-10
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.06.024
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Long-term exposure to fluoride may affect activities of many enzymes.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Fluoride can enhance processes of inflammation or proliferation in monocytes/activated macrophages.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Cyclooxygenase 2 (COX-2) induction increases in response to pro-inflammatory stimuli.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">In this study we aimed to verify whether the NaF can change prostanoids biosynthesis in THP-1 macrophages.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">The changes in prostanoids biosynthesis indicate the COX-2 activity.</p> </list-item> </list> </p> </sec> </abstract>