Fluoride as a factor initiating and potentiating inflammation in THP1 differentiated monocytes/macrophages. Issue 7 (October 2015) - Gutowska, I.
Highlights Long-term exposure to fluoride may affect activities of many enzymes. Fluoride can enhance processes of inflammation or proliferation in monocytes/activated macrophages. Cyclooxygenase 2 (COX-2) induction increases in response to pro-inflammatory stimuli. In this study we aimed to verify whether the NaF can change prostanoids biosynthesis in THP-1 macrophages. The changes in prostanoids biosynthesis indicate the COX-2 activity.