Dynamics of ceramide generation and metabolism in response to fenretinide – Diversity within and among leukemia. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Morad, Samy A.F.; Davis, Traci S.; Kester, Mark; Loughran, Thomas P.; Cabot, Myles C.
• Is Part Of: Leukemia research. Volume 39:Issue 10(2015:Oct.)
• Page Start: 1071
• Page End: 1078
• Publication Date: 2015-10
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.009
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Leukemias display diverse sensitivities to fenretinide.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Fenretinide enhances ceramide levels by <italic>de novo</italic> and sphingomyelinase pathways.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Ceramide is metabolized differently in different leukemias (AML, CML, CLL).</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Dysfunctional ceramide generation correlates with fenretinide resistance.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Ceramide metabolic signatures can be helpful in directing clinical use of fenretinide.</p> </list-item> </list> </p> </sec> </abstract>