Dynamics of ceramide generation and metabolism in response to fenretinide – Diversity within and among leukemia. Issue 10 (October 2015) - Morad, Samy A.F.
Highlights Leukemias display diverse sensitivities to fenretinide. Fenretinide enhances ceramide levels by de novo and sphingomyelinase pathways. Ceramide is metabolized differently in different leukemias (AML, CML, CLL). Dysfunctional ceramide generation correlates with fenretinide resistance. Ceramide metabolic signatures can be helpful in directing clinical use of fenretinide.