Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals. Issue 2 (October 2015)

• Record Type: Journal Article
• Authors: Fernandes, Marcos T.P.; Fernandes, Karen B.P.; Marquez, Audrey S.; Cólus, Ilce M.S.; Souza, Marilesia F.; Santos, João Paulo M.; Poli-Frederico, Regina C.
• Is Part Of: Cytokine. Volume 75:Issue 2(2015)
• Page Start: 316
• Page End: 320
• Publication Date: 2015-10
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.07.020
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Individuals carrying the C allele of <italic>IL6</italic> gene have lower susceptibility to osteoarthritis.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">The C allele of <italic>IL6</italic> gene was associated with minor radiological impairment in hip and knee osteoarthritis.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Patients with osteoarthritis with C allele of <italic>IL6</italic> gene have better functional status according to WOMAC questionnaire.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Individuals harboring GC or CC genotypes of <italic>IL6</italic> gene have a reduction in IL-6 serum levels.</p> </list-item> </list> </p> </sec> </abstract>