Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals. Issue 2 (October 2015) - Fernandes, Marcos T.P.
Highlights Individuals carrying the C allele of IL6 gene have lower susceptibility to osteoarthritis. The C allele of IL6 gene was associated with minor radiological impairment in hip and knee osteoarthritis. Patients with osteoarthritis with C allele of IL6 gene have better functional status according to WOMAC questionnaire. Individuals harboring GC or CC genotypes of IL6 gene have a reduction in IL-6 serum levels.