Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of New Biaryl‐Diphosphine Ligands. Issue 13 (10th September 2015)

• Record Type: Journal Article
• Authors: Graff, Julien; Łastawiecka, Elżbieta; Guénée, Laure; Leroux, Frédéric; Alexakis, Alexandre
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 13(2015)
• Page Start: 2833
• Page End: 2839
• Publication Date: 2015-09-10
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500323
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The desymmetrization of the prochiral tetrabromobiphenyl <italic>via</italic> asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl‐diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one‐ to three‐step reactions in good to excellent yields.</p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2n0t64c9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>