Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of New Biaryl‐Diphosphine Ligands. Issue 13 (10th September 2015) - Graff, Julien
Abstract The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl‐diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one‐ to three‐step reactions in good to excellent yields.