Reliability of magnetic resonance elastography using multislice two‐dimensional spin‐echo echo‐planar imaging (SE‐EPI) and three‐dimensional inversion reconstruction for assessing renal stiffness. Issue 3 (24th December 2014)

• Record Type: Journal Article
• Authors: Low, Gavin; Owen, Nicola E.; Joubert, Ilse; Patterson, Andrew J.; Graves, Martin J.; Glaser, Kevin J.; Alexander, Graeme J.M.; Lomas, David J.
• Is Part Of: Journal of magnetic resonance imaging. Volume 42:Issue 3(2015)
• Page Start: 844
• Page End: 850
• Publication Date: 2014-12-24
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24826
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24826-sec-0001" sec-type="section"> <title>Background</title> <p>To evaluate the reliability of MRE using a spin‐echo echo‐planar imaging (SE‐EPI) renal MRE technique in healthy volunteers.</p> </sec> <sec id="jmri24826-sec-0002" sec-type="section"> <title>Methods</title> <p>Institutional review board approved prospective study in which all participants provided written informed consent. Sixteen healthy volunteers comprising seven males and nine females with a median age of 35 years (age range: 23 to 59 years) were included. Coronal 90 Hz and 60 Hz MRE acquisitions were performed twice within a 30‐min interval between examinations. Renal MRE reliability was assessed by (i) test–retest repeatability, and (ii) inter‐rater agreement between two independent readers. The MRE‐measured averaged renal stiffness values were evaluated using: intraclass correlation coefficient (ICC), Bland‐Altman and the within‐subject coefficient of variation (COV).</p> </sec> <sec id="jmri24826-sec-0003" sec-type="section"> <title>Results</title> <p>For test–retest repeatability, Bland‐Altman showed a mean stiffness difference between examinations of 0.07 kPa (95% limits of agreement: −1.41, 1.54) at 90 Hz and 0.01 kPa (95% limits of agreement: −0.51, 0.53) at 60 Hz. Coefficient of repeatability was 1.47 kPa and 0.52 kPa at 90 Hz and 60 Hz, respectively. The within‐subject COV was 13.6% and 7.7% at 90 Hz and 60 Hz, respectively. ICC values were 0.922 and 0.907 for test–retest repeatability and 0.998 and 0.989 for inter‐rater agreement, respectively (<italic>P</italic> < 0.001).</p> </sec> <sec id="jmri24826-sec-0004" sec-type="section"> <title>Conclusion</title> <p>SE‐EPI renal MRE is a reliable technique. J. Magn. Reson. Imaging 2015;42:844–850.</p> </sec> </abstract>