The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. Issue 3 (17th September 2015)

• Record Type: Journal Article
• Authors: Lu, Xiaolin; Luo, Fei; Liu, Yi; Zhang, Aihua; Li, Jun; Wang, Bairu; Xu, Wenchao; Shi, Le; Liu, Xinlu; Lu, Lu; Liu, Qizhan
• Is Part Of: Toxicology letters. Volume 237:Issue 3(2015)
• Page Start: 191
• Page End: 199
• Publication Date: 2015-09-17
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.06.011
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0065"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Arsenite evokes IL-6 secretion and induces inflammation of human keratinocytes.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IL-6 autocrine activates STAT3 signaling and up-regulates miR-21expression</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">MiR-21 regulated by STAT3 is involved in arsenite-induced epithelial-mesenchymal transition (EMT) and promotes migration and invasion.</p> </list-item> </list> </p> </sec> </abstract>