The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. Issue 3 (17th September 2015) - Lu, Xiaolin
Highlights Arsenite evokes IL-6 secretion and induces inflammation of human keratinocytes. IL-6 autocrine activates STAT3 signaling and up-regulates miR-21expression MiR-21 regulated by STAT3 is involved in arsenite-induced epithelial-mesenchymal transition (EMT) and promotes migration and invasion.