FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Issue 1 (28th June 2015)

• Record Type: Journal Article
• Authors: Jin, Yue; Shenoy, Anitha K.; Doernberg, Samuel; Chen, Hao; Luo, Huacheng; Shen, Huangxuan; Lin, Tong; Tarrash, Miriam; Cai, Qingsong; Hu, Xin; Fiske, Ryan; Chen, Ting; Wu, Lizi; Mohammed, Kamal A.; Rottiers, Veerle; Lee, Siu Sylvia; Lu, Jianrong
• Is Part Of: Cancer letters. Volume 362:Issue 1(2015)
• Page Start: 70
• Page End: 82
• Publication Date: 2015-06-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.037
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">FBXO11 interacts with and degrades the EMT-driving Snail transcription factors.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">FBXO11 inhibits EMT and tumor invasion and is a favorable prognostic factor.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">FBXO11 deficient mice show increased Snail protein levels and epidermal hyperplasia.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Epistasis analysis in <italic>C. elegans</italic> validates the FBXO11-Snail regulatory axis.</p> </list-item> </list> </p> </sec> </abstract>