FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Issue 1 (28th June 2015) - Jin, Yue
Highlights FBXO11 interacts with and degrades the EMT-driving Snail transcription factors. FBXO11 inhibits EMT and tumor invasion and is a favorable prognostic factor. FBXO11 deficient mice show increased Snail protein levels and epidermal hyperplasia. Epistasis analysis in C. elegans validates the FBXO11-Snail regulatory axis.