Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis. Issue 15 (8th April 2015)

• Record Type: Journal Article
• Authors: Arnold, Isabelle C.; Hutchings, Claire; Kondova, Ivanela; Hey, Ariann; Powrie, Fiona; Beverley, Peter; Tchilian, Elma
• Is Part Of: Vaccine. Volume 33:Issue 15(2015)
• Page Start: 1808
• Page End: 1814
• Publication Date: 2015-04-08
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.02.041
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Neonatal <italic>Hh</italic> infection of mice upregulates colonic IL10 message.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Neonatal <italic>Hh</italic> infection reduces lung immune responses after immunisation with Ad85A.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Protection against <italic>Mtb</italic> challenge induced by Ad85A is abolished in <italic>Hh</italic> infected mice.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IL10R blockade reverses the effects of <italic>Hh</italic> infection on Ad85A induced protection.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Addition of <italic>Hh</italic> to the microbiota abolishes protection induced by a subunit vaccine.</p> </list-item> </list> </p> </sec> </abstract>