Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis. Issue 15 (8th April 2015) - Arnold, Isabelle C.
Highlights Neonatal Hh infection of mice upregulates colonic IL10 message. Neonatal Hh infection reduces lung immune responses after immunisation with Ad85A. Protection against Mtb challenge induced by Ad85A is abolished in Hh infected mice. IL10R blockade reverses the effects of Hh infection on Ad85A induced protection. Addition of Hh to the microbiota abolishes protection induced by a subunit vaccine.