The p16INK4A/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Chien, Wei W.; Catallo, Régine; Chebel, Amel; Baranger, Laurence; Thomas, Xavier; Béné, Marie-Christine; Gerland, Luc M.; Schmidt, Aline; Beldjord, Kheira; Klein, Nathalie; Escoffre-Barbe, Martine; Leguay, Thibaut; Huguet, Françoise; Larosa, Fabrice; Hayette, Sandrine; Plesa, Adriana; Ifrah, Norbert; Dombret, Hervé; Salles, Gilles; Chassevent, Agnès; Ffrench, Martine
• Is Part Of: Leukemia research. Volume 39:Issue 4(2015:Apr.)
• Page Start: 453
• Page End: 461
• Publication Date: 2015-04
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.01.008
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">New prognosis markers are needed in Adult BCP-ALL prospective trials.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The p16^INK4A/CDK4-6/pRb pathway and telomerase activity were analyzed in 123 cases.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">These variables appeared as new prognostic markers in the <italic>BCR-ABL1</italic>^{<italic>+</italic>} subgroup.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">In vitro analysis suggested that this poor prognosis may be related to cell activation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">These findings argue for the development of new therapeutic strategies in <italic>BCR-ABL1</italic>^{<italic>+</italic>} ALL.</p> </list-item> </list> </p> </sec> </abstract>