The p16INK4A/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome. Issue 4 (April 2015) - Chien, Wei W.
Highlights New prognosis markers are needed in Adult BCP-ALL prospective trials. The p16INK4A/CDK4-6/pRb pathway and telomerase activity were analyzed in 123 cases. These variables appeared as new prognostic markers in the BCR-ABL1+ subgroup. In vitro analysis suggested that this poor prognosis may be related to cell activation. These findings argue for the development of new therapeutic strategies in BCR-ABL1+ ALL.