Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis. Issue 11 (10th March 2015)

• Record Type: Journal Article
• Authors: Sander, Peter; Clark, Simon; Petrera, Agnese; Vilaplana, Cristina; Meuli, Michael; Selchow, Petra; Zelmer, Andrea; Mohanan, Deepa; Andreu, Nuria; Rayner, Emma; Dal Molin, Michael; Bancroft, Gregory J.; Johansen, Pål; Cardona, Pere-Joan; Williams, Ann; Böttger, Erik C.
• Is Part Of: Vaccine. Volume 33:Issue 11(2015)
• Page Start: 1353
• Page End: 1359
• Publication Date: 2015-03-10
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.01.058
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">BCG <italic>zmp1</italic> mutants confer increased protection in a guinea pig model of TB as compared to BCG.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The improved protective efficacy of <italic>zmp1</italic> deletion mutants is independent on the BCG sub-strain.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">BCG <italic>zmp1</italic> deletion mutants demonstrate an improved safety profile in a SCID mouse model.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">BCG <italic>zmp1</italic> mutants are promising candidates for further vaccine development due to their protective efficacy and safety profile.</p> </list-item> </list> </p> </sec> </abstract>