Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis. Issue 11 (10th March 2015) - Sander, Peter
Highlights BCG zmp1 mutants confer increased protection in a guinea pig model of TB as compared to BCG. The improved protective efficacy of zmp1 deletion mutants is independent on the BCG sub-strain. BCG zmp1 deletion mutants demonstrate an improved safety profile in a SCID mouse model. BCG zmp1 mutants are promising candidates for further vaccine development due to their protective efficacy and safety profile.