Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus. Issue 2 (June 2015)

• Record Type: Journal Article
• Authors: Hehle, Verena; Fraser, Louise D.; Tahir, Romeeza; Kipling, David; Wu, Yu-Chang; Lutalo, Pamela M.K.; Cason, John; Choong, LeeMeng; D'Cruz, David P.; Cope, Andrew P.; Dunn-Walters, Deborah K.; Spencer, Jo
• Is Part Of: Molecular immunology. Volume 65:Issue 2(2015:Jun.)
• Page Start: 215
• Page End: 223
• Publication Date: 2015-06
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.01.017
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0060"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005">Groups of immunoglobulin kappa light chain gene (IGK) rearrangements were compared.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Positive and negative selection of IGK gene segments during repertoire development was identified.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Productive rearrangements of IGKs can be rejected in favour of rearrangement of IGL.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Although IGKV4.1 may not be selected against during B cell development, expression may be suppressed.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Suppression of expression of IGKV4.1 appears to be defective in SLE.</p> </list-item> </list> </p> </sec> </abstract>