Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus. Issue 2 (June 2015) - Hehle, Verena
Highlights Groups of immunoglobulin kappa light chain gene (IGK) rearrangements were compared. Positive and negative selection of IGK gene segments during repertoire development was identified. Productive rearrangements of IGKs can be rejected in favour of rearrangement of IGL. Although IGKV4.1 may not be selected against during B cell development, expression may be suppressed. Suppression of expression of IGKV4.1 appears to be defective in SLE.