Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma. Issue 2 (1st May 2015)

• Record Type: Journal Article
• Authors: Xiao, Zhenyu; Chung, Haniee; Banan, Babak; Manning, Pamela T.; Ott, Katherine C.; Lin, Shin; Capoccia, Benjamin J.; Subramanian, Vijay; Hiebsch, Ronald R.; Upadhya, Gundumi A.; Mohanakumar, Thalachallour; Frazier, William A.; Lin, Yiing; Chapman, William C.
• Is Part Of: Cancer letters. Volume 360:Issue 2(2015)
• Page Start: 302
• Page End: 309
• Publication Date: 2015-05-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.02.036
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">First time demonstrating that CD47 blockade has anti-tumor effects against HCC.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015"> <italic>In vitro</italic> CD47 blockade results in increase in phagocytosis of HCC cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>In vivo</italic> CD47 blockade inhibits HCC tumor growth in hetero/orthotopic models.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">CD47mAb400 is clearly more efficacious than widely-investigated B6H12 antibody.</p> </list-item> </list> </p> </sec> </abstract>