Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma. Issue 2 (1st May 2015) - Xiao, Zhenyu
Highlights First time demonstrating that CD47 blockade has anti-tumor effects against HCC. In vitro CD47 blockade results in increase in phagocytosis of HCC cells. In vivo CD47 blockade inhibits HCC tumor growth in hetero/orthotopic models. CD47mAb400 is clearly more efficacious than widely-investigated B6H12 antibody.