Association of n-3 polyunsaturated fatty acids and inflammatory indicators with renal function decline in type 2 diabetes. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Chung, Hsin-Fang; Long, Kurt Z.; Hsu, Chih-Cheng; Al Mamun, Abdullah; Jhang, Huei-Ru; Shin, Shyi-Jang; Hwang, Shang-Jyh; Huang, Meng-Chuan
• Is Part Of: Clinical nutrition. Volume 34:Issue 2(2015:Apr.)
• Page Start: 229
• Page End: 234
• Publication Date: 2015-04
• Subjects: Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2014.02.009
• Languages: English
• ISSNs: 0261-5614

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Background & aims</title> <p id="abspara0010">The n-3 polyunsaturated fatty acids (PUFAs) and the inflammatory indicator, interleukin-6 (IL-6), have been implied in the development of renal dysfunction. This longitudinal study examined the effect of n-3 PUFAs and IL-6 on the risk of renal function decline and explored whether n-3 PUFAs modify the effect of inflammatory indicators on renal dysfunction risk in type 2 diabetes.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Studying 676 type 2 diabetic patients, we analyzed erythrocyte fatty acids and inflammatory markers in 2008 and estimated glomerular filtration rate (eGFR) in 2008 and 2012. Renal function decline was defined as an eGFR decline of ≥25% over a 4-year period.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Multivariable logistic regression revealed erythrocyte total PUFAs, n-3 PUFAs, and n-3/n-6 PUFA ratio correlated negatively with risk of renal function decline (OR = 0.75, 0.78, and 0.61, respectively, all <italic>p</italic> < 0.01), while n-6 PUFAs did not. IL-6 independently predicted risk of renal dysfunction (OR = 1.18, <italic>p</italic> = 0.015). Stratifying erythrocyte PUFAs into low (<50<sup>th</sup> percentile) or high group (≥50<sup>th</sup> percentile), we found a positive association between IL-6 and risk of renal dysfunction only in the low n-3 PUFA (OR = 1.27, <italic>p</italic> = 0.035), low n-3/n-6 PUFA (OR = 1.27, <italic>p</italic> = 0.034), and low total PUFA groups (OR = 1.36, <italic>p</italic> = 0.005), but not in the high groups.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">High PUFA concentrations, especially n-3 or higher n-3/n-6 PUFA ratio, may exert protective effects against renal function impairment in type 2 diabetic patients. Whether the effect is mediated via modification of inflammatory biomarker such as IL-6 by high n-3 PUFA status warrants further investigation.</p> </sec> </abstract>