Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Frizzell, Caroline; Uhlig, Silvio; Miles, Christopher O.; Verhaegen, Steven; Elliott, Christopher T.; Eriksen, Gunnar S.; Sørlie, Morten; Ropstad, Erik; Connolly, Lisa
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 575
• Page End: 581
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.01.006
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st080">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0160">Zearalenone and zearalenol glucuronides were investigated for estrogenic activity.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0165">Reporter gene assays and confirmatory mass spectrometry were utilised.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0170">Any weak estrogenicity observed was due to deconjugation of the glucuronide moiety.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0175">Zearalenone glucuronide formation is a detoxification step regarding estrogenicity.</p> </list-item> </list> </p> </sec> </abstract>