Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity. Issue 3 (April 2015) - Frizzell, Caroline
Highlights Zearalenone and zearalenol glucuronides were investigated for estrogenic activity. Reporter gene assays and confirmatory mass spectrometry were utilised. Any weak estrogenicity observed was due to deconjugation of the glucuronide moiety. Zearalenone glucuronide formation is a detoxification step regarding estrogenicity.