Effect of white wheat bread and white wheat bread added with bioactive compounds on hypercholesterolemic and steatotic mice fed a high‐fat diet. (24th November 2014)

• Record Type: Journal Article
• Authors: Pozzo, Luisa; Pucci, Laura; Buonamici, Guglielmo; Giorgetti, Lucia; Maltinti, Maristella; Longo, Vincenzo
• Is Part Of: Journal of the science of food and agriculture. Volume 95:Number 12(2015:Sep. 15)
• Page Start: 2454
• Page End: 2461
• Publication Date: 2014-11-24
• Subjects: Food -- Periodicals; Agriculture -- Periodicals; 664
• DOI: 10.1002/jsfa.6972
• Languages: English
• ISSNs: 0022-5142

Abstract

<abstract abstract-type="main" id="jsfa6972-abs-0001"> <title>Abstract</title> <sec id="jsfa6972-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p id="jsfa6972-para-0001">The effects of white wheat bread and white wheat bread added with a bioactive compound mixture (<italic>Cyclanthera pedata</italic>, <italic>Glycine max</italic>, <italic>Monascus</italic>‐fermented red mold rice, <italic>Cynara scolymus</italic> and <italic>Medicago sativa</italic>) were examined on hypercholesterolemic and steatotic mice, divided into four groups: control diet (CTR), high‐fat diet (HFD), high‐fat diet with white wheat bread added with 1.5 g kg<sup>−1</sup> of mixture (HFD+AB) and high‐fat diet with white wheat bread (HFD+B).</p> </sec> <sec id="jsfa6972-sec-0002" sec-type="section"> <title>RESULTS</title> <p id="jsfa6972-para-0002">Total serum cholesterol in the HFD+AB and HFD+B groups and hepatic triglycerides in the HFD+AB group decreased compared with the HFD group. Liver histology confirmed lower lipid drop accumulation in the HFD+AB group than in the HFD and HFD+B groups. HFD+AB caused a 7.0‐fold increase and a 3.5‐fold reduction in CYP7A1 and SREBP‐1c gene expression respectively compared with the HFD group. Moreover, the HFD+B group showed a 2.2‐, 8.4‐ and 1.5‐fold increase in HMG CoA reductase, CYP7A1 and LDLr gene expression respectively compared with the HFD group.</p> </sec> <sec id="jsfa6972-sec-0003" sec-type="section"> <title>CONCLUSION</title> <p id="jsfa6972-para-0003">Both the white wheat bread and the added white wheat bread induced cholesterol reduction by increasing CYP7A1. Moreover, the added white wheat bread improved steatosis by decreasing SREBP‐1c gene expression. © 2014 Society of Chemical Industry</p> </sec> </abstract>