Anti‐Amyloidogenic Properties of Dryopteris Crassirhizoma Roots in Alzheimer's Disease Cellular Model. Issue 4 (26th May 2015)

• Record Type: Journal Article
• Authors: Kim, Jae‐Moon; Hwang, Kwang Woo; Joo, Hwan‐Bin; Park, So‐Young
• Is Part Of: Journal of food biochemistry. Volume 39:Issue 4(2015:Aug.)
• Page Start: 478
• Page End: 484
• Publication Date: 2015-05-26
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Biochemistry -- Periodicals; 664.024
• DOI: 10.1111/jfbc.12156
• Languages: English
• ISSNs: 0145-8884

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jfbc12156-sec-1001" sec-type="section"> <p>The inhibitory effects of <italic>D</italic><italic>ryopteris crassirhizoma</italic> roots on Aβ production, which is one of the major causes of Alzheimer's disease, were investigated as they have not been studied at all. The methanol extract of <italic>D</italic><italic>. crassirhizoma</italic> roots significantly reduced the production of Aβ in Chinese Hamster Ovarian cells overexpressing amyloid precursor proteins (APPs). This reduction was more pronounced with the butanol layer of <italic>D</italic><italic>. crassirhizoma</italic> roots, which is partitioned based on solvent polarity. In addition, reduced production of Aβ by <italic>D</italic><italic>. crassirhizoma</italic> roots was accompanied with increased production of sAPPβ, which is a proteolytic fragment of APP by β‐secretases. The expression of β‐secretases was also decreased by treatment with <italic>D</italic><italic>. crassirhizoma</italic> roots. Furthermore, the amount of CTFα, a proteolytic fragment of APP by α‐secretases, is significantly increased by <italic>D</italic><italic>. crassirhizoma</italic> roots. These results indicate that <italic>D</italic><italic>. crassirhizoma</italic> roots efficiently decreased Aβ production by inhibiting β‐secretases and increasing α‐secretases.</p> </sec> <sec id="jfbc12156-sec-1002" sec-type="section"> <title>Practical Applications</title> <p> <italic>D</italic> <italic>ryopteris crassirhizoma</italic> roots efficiently reduced Aβ production. Therefore, <italic>D</italic><italic>. crassirhizoma</italic> has the potential to be developed into an anti‐Aβ agent, which may have beneficial effects for the prevention or treatment of Alzheimer's disease.</p> </sec> </abstract>