Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta‐analysis of nine studies in the CHARGE consortium. Issue 7 (16th March 2015)

• Record Type: Journal Article
• Authors: Smith, Caren E.; Follis, Jack L.; Nettleton, Jennifer A.; Foy, Millennia; Wu, Jason H.Y.; Ma, Yiyi; Tanaka, Toshiko; Manichakul, Ani W.; Wu, Hongyu; Chu, Audrey Y.; Steffen, Lyn M.; Fornage, Myriam; Mozaffarian, Dariush; Kabagambe, Edmond K.; Ferruci, Luigi; Chen, Yii‐Der Ida; Rich, Stephen S.; Djoussé, Luc; Ridker, Paul M.; Tang, Weihong; McKnight, Barbara; Tsai, Michael Y.; Bandinelli, Stefania; Rotter, Jerome I.; Hu, Frank B.; Chasman, Daniel I.; Psaty, Bruce M.; Arnett, Donna K.; King, Irena B.; Sun, Qi; Wang, Lu; Lumley, Thomas; Chiuve, Stephanie E.; Siscovick, David S.; Ordovás, José M.; Lemaitre, Rozenn N.;
• Is Part Of: Molecular nutrition & food research. Volume 59:Issue 7(2015:Jul.)
• Page Start: 1373
• Page End: 1383
• Publication Date: 2015-03-16
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201400734
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2341-sec-0010" sec-type="section"> <title>Scope</title> <p>Tissue concentrations of omega‐3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega‐3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha‐linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid.</p> </sec> <sec id="mnfr2341-sec-0020" sec-type="section"> <title>Methods and results</title> <p>We conducted meta‐analyses (<italic>N</italic> = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in <italic>FADS1</italic> (fatty acid desaturase 1), rs7435 in <italic>AGPAT3</italic> (1‐acyl‐sn‐glycerol‐3‐phosphate), rs4985167 in <italic>PDXDC1</italic> (pyridoxal‐dependent decarboxylase domain‐containing 1), rs780094 in <italic>GCKR</italic> (glucokinase regulatory protein), and rs3734398 in <italic>ELOVL2</italic> (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment‐specific interactions between <italic>FADS1</italic> rs174538 and rs174548 and dietary alpha‐linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid.</p> </sec> <sec id="mnfr2341-sec-0030" sec-type="section"> <title>Conclusion</title> <p>Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene–diet relationships, and considering compartment may improve the detection of gene–fatty acids interactions for circulating fatty acid outcomes.</p> </sec> </abstract>