Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases1. Issue 18 (14th May 2015)

• Record Type: Journal Article
• Authors: Miller, Duncan C.; Carbain, Benoit; Beale, Gary S.; Alhasan, Sari F.; Reeves, Helen L.; Baisch, Ulrich; Newell, David R.; Golding, Bernard T.; Griffin, Roger J.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 18(2015)
• Page Start: 5279
• Page End: 5284
• Publication Date: 2015-05-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00211g
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj14j7hxpg" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />An improved synthesis from <sc>d</sc>-glucosamine of a purported Sulf-2 inhibitor is described, with assay data for this compound and analogues showing only weak inhibition of Sulf-2, and sulfatases ARSA or ARSB.</p> </abstract>