Phospholipid oxidation generates potent anti‐inflammatory lipid mediators that mimic structurally related pro‐resolving eicosanoids by activating Nrf2. Issue 5 (13th March 2015)

• Record Type: Journal Article
• Authors: Bretscher, Peter; Egger, Julian; Shamshiev, Abdijapar; Trötzmüller, Martin; Köfeler, Harald; Carreira, Erick M; Kopf, Manfred; Freigang, Stefan
• Is Part Of: EMBO molecular medicine. Volume 7:Issue 5(2015:May)
• Page Start: 593
• Page End: 607
• Publication Date: 2015-03-13
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201404702
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="emmm201404702-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study characterizes the potent anti‐inflammatory bioactivity of oxidized phospholipids and identifies a fatty acid epoxycyclopentenone as the active component that triggers Nrf2 signaling in myeloid cells and alleviates inflammation and endotoxin‐induced lung injury in a mouse model.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjk6vsckh" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>