Phospholipid oxidation generates potent anti‐inflammatory lipid mediators that mimic structurally related pro‐resolving eicosanoids by activating Nrf2. Issue 5 (13th March 2015) - Bretscher, Peter
Abstract This study characterizes the potent anti‐inflammatory bioactivity of oxidized phospholipids and identifies a fatty acid epoxycyclopentenone as the active component that triggers Nrf2 signaling in myeloid cells and alleviates inflammation and endotoxin‐induced lung injury in a mouse model.