Enzymatic preparation of t-butyl-6-cyano-(3R, 5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Wu, Xuri; Gou, Xudong; Chen, Yijun
• Is Part Of: Process biochemistry. Volume 50:Issue 1(2015:Jan.)
• Page Start: 104
• Page End: 110
• Publication Date: 2015-01
• Subjects: Biochemical engineering -- Periodicals; Biotechnology -- Periodicals; Biochemistry -- periodicals; Biotechnology -- periodicals; Chemical Engineering -- periodicals; Génie biochimique -- Périodiques; Biotechnologie -- Périodiques; Biochemical engineering; Biotechnology; Periodicals; 660.63
• DOI: 10.1016/j.procbio.2014.10.023
• Languages: English
• ISSNs: 1359-5113

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Co-expression of carbonyl reductase and glucose dehydrogenase was achieved in a favorable order.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Exogenous addition of cofactors was completely eliminated for the bioreduction.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Whole-cell based biocatalytic process was established for the preparation of statin side chains.</p> </list-item> </list> </p> </sec> </abstract>