IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Cheng, Wenjing; Zhao, Qing; Xi, Yebin; Li, Chengzhen; Xu, Yunzhi; Wang, Li; Niu, Xiaoyin; Wang, Zhaojun; Chen, Guangjie
• Is Part Of: Molecular immunology. Volume 64:Issue 1(2015:Mar.)
• Page Start: 152
• Page End: 162
• Publication Date: 2015-03
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.11.012
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We found that IFN-β can significantly inhibit the severity of EAE disease.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IFN-β decreased the expressions of chemokines in CNS.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">IFN-β decreased the infiltration of activated encephalitogenic T cells into CNS.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IFN-β reduced the CCL2/CCL5 induced T cells migration by inhibiting the p38-MAPK and ERK1/2 activation.</p> </list-item> </list> </p> </sec> </abstract>