IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis. Issue 1 (March 2015) - Cheng, Wenjing
Highlights We found that IFN-β can significantly inhibit the severity of EAE disease. IFN-β decreased the expressions of chemokines in CNS. IFN-β decreased the infiltration of activated encephalitogenic T cells into CNS. IFN-β reduced the CCL2/CCL5 induced T cells migration by inhibiting the p38-MAPK and ERK1/2 activation.